NOT KNOWN DETAILS ABOUT FENTANYL TOXICITY SIGNS AND SYMPTOMS

ribociclib will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.If coadministration of CYP3A4 inhibitors with fentanyl is important, monitor patients for respiratory depression and sedation at frequent intervals and consider fentanyl dose adjustments until eventually stable drug effects are achieved.